Cisplatin ic50 sh-sy5y

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WebOct 30, 2012 · SH-SY5Y cells were seeded in 6-well plates (at 2×10 6 /ml) and incubated for 24 h until they were treated with 0.1 μM VCR for 6, 12, 18 and 24 h. Non-treated cells at 0 h were used as the control group. Cells were washed twice with ice-cold PBS and fixed with 70% ice-cold ethanol. WebSep 16, 2005 · Human neuroblastoma SH-SY5Y cells (1.5 × 10 6 per 60-mm dish) were plated and after 24 hours were treated with 4 μmol/L CDDP, 1 μmol/L paclitaxel alone, or …

Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y …

Webcomplexes 2 and 3 resulting in greater cell uptake than cisplatin in selected tumor cell lines, only 3 showed comparable or higher antitumor activity. General low cytotoxicity of complex 2 in the tested cell lines (SH-SY5Y, SK-OV-3, Hep-G2, Caco-2, HeLa, MCF-7, MG-63, ZL-65) appeared to depend WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. ... recent studies indicated an effective inhibitory effect by ginkgolic acid C17:1, with IC50 values of less than 2 μM, ... in potassium chloride-induced α-synuclein aggregates in SH ... greencroft pond

Neuroprotective and antioxidant lanostanoid triterpenes from …

WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebThe IC25 and IC50 values of NaF for 3, 12 and 24 h and optimum dose of increase in proliferation to vitamin D3 through MTT assay in NRK-52E kidney cells were determined. DNA damage was signiﬁcantly increased (p < 0.05) compared to the control group in all groups except for vitamin D3. WebOct 23, 2024 · Cisplatin 5 µg and different concentrations (Cisplatin + CoS NPs bioconjugates (5, 10, 25, 50, 75 μg) doses were applied to SH-SY5Y neuroblastoma cell lines for 24 h. TAC, TOS and MTT tests were performed 24 h after the application. floydhampton mail.com

Effect of CDDP and OHP treatment on SH-SY5Y cell

Alterations in the matrix metalloproteinase-3 promoter …

WebAs a result, compounds 2 and 5 exhibited potent neuroprotective activity against 6-OHDA-induced cell death in SH-SY5Y cells with the lowest IC50 value (0.5 μM) while compounds 1, 3 and 4 possessed significant neuroprotective activity with IC50 value less than 10 μM. WebAn IC50 curve for MCF7 cells treated with cisplatin. Percentage cell survival is plotted against the logarithm of treatment concentrations. Data points are the means±SD of duplicate... green croft premierWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … greencroft park

"WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and … " - Cisplatin ic50 sh-sy5y

Cisplatin ic50 sh-sy5y

IC50 values for (a-d) bortezomib-and (e-h) cisplatin-treated …

WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), … WebCytotoxic effects of DXR towards SH-SY5Y seemed to cause degradation of the extracellular matrix, since all cells were dismantled from the spheroid upon cell death. On the other hand, 293T spheroids revealed retarded cellular activity and ATP productions upon DXR treatment throughout the experiment.

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WebMay 11, 2016 · Table 3 Comparison of doxorubicin IC50 values of A549, 293T, HeLa, U2OS, and SH-SY5Y spheroids and effects over the incubation times Abbreviation: NR, IC50 not reached. After 24 hrs, 4 out of 5 of the spheroids did not show any significant change in their metabolic activity, when incubated with increasing concentrations of DXR. WebOct 25, 2016 · The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer Oncotarget 2016 Oct 25;7 (43):70803-70821. doi: 10.18632/oncotarget.12223. Authors

WebOct 23, 2024 · Cisplatin 5 µg and different concentrations (Cisplatin + CoS NPs bioconjugates (5, 10, 25, 50, 75 μg) doses were applied to SH-SY5Y neuroblastoma cell … WebSH-SY5Y were deposited to the ATCC(®) in 1970 by June L. Biedler.Three important characteristics of SH-SY5Y cells should be considered when using these cells in in vitro studies. First, cultures include both adherent and floating cells, both types of …

WebNov 2, 2024 · IC 50 values for single methotrexate treatments were 1.2 µM (R 2 = 0.9624) for MCF-7, and 0.8 µM (R 2 = 0.9583) for SH-SY5Y cells (Fig. 1 ). Therefore, combination doses of methotrexate were calculated and used according to these values. Webγ-Mangostin is a xanthone with hydroxyl groups that confer the substance-free radical scavenging effects. As opposed to the other more extensively studied mangostins, scarce research has been conducted on neuroprotective effects of γ-mangostin on

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WebThe IC50 values of the two platinum derivatives varied considerably. The values for cisplatin varied between 0.022 microgram ml-1 and 0.56 microgram ml-1 and the corresponding values for carboplatin were 0.096-1.20 microgram ml-1. The range of the ratios between carboplatin IC50 and cisplatin IC50, from 1.5:1 to 4.4:1, was rather narrow. floyd green wifeWebOct 1, 2024 · Applying the abovementioned molecular modeling procedure yielded four compounds of LSD1/CoREST inhibiters with IC50 < 2µM. The four lead compounds were tested against SH-SY5Y neuroblastoma cell line that known to express high level of LSD1 and illustrated a potent activity with an IC50 ranging from 0.195 to 1.52µM. greencroft nursery herefordWeb0.744770. Filter: 760 entries 1 2 3 ... 31 CSV TAB XLS. The Genomics of Drug Sensitivity in Cancer Project is a collaboration between the Cancer Genome Project at the Wellcome Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is funded by Wellcome . floyd handmade music schoolWebOct 1, 2024 · The purpose of this study was to evaluate the effect of 50-Hz electromagnetic field (EMF) in combination with CDDP and bleomycin (Bleo) on expression of some of DNA repair genes (GADD45A, XRCC1,... floyd hare and tortoise algorithmWebJul 20, 2024 · In this analysis, 10 × 10 3 SH-SY5Y cells were plated in 96-wells. 10 mM stocks of ME0053, ME0055 and ME0192 compounds were diluted in DMEM to obtain the treatment doses of 50 µM, 100 µM, 150 µM and 200 µM. Treated- and control groups were incubated for 24 h at 37 °C and %5 CO 2. greencroft recreation center reconstructionWebThe City of Fawn Creek is located in the State of Kansas. Find directions to Fawn Creek, browse local businesses, landmarks, get current traffic estimates, road conditions, and … greencroft of goshenWebJun 18, 2004 · Abstract In human SH-SY5Y neuroblastoma cells, two distinct intracellular Ca2+ stores, a KCl-/caffeine-sensitive and a carbachol-/IP3-sensitive store, were demonstrated previously. In this study, responses of these two intracellular Ca2+ stores to thapsigargin were characterized. greencroft playground