Dynein light intermediate chain
WebKASH5 interacts with a dynein light intermediate chain (DYNC1LI1 or DYNC1LI2) via a conserved helix in the LIC C-terminal, and this region is also needed for dynein's recruitment to other cellular membranes. KASH5's N-terminal EF-hands are essential as the interaction with dynein is disrupted by mutation of key calcium-binding residues ... WebJul 21, 2004 · Intraflagellar transport (IFT), the bidirectional movement of particles along flagella, is essential for flagellar assembly. The motor for retrograde IFT in Chlamydomonas is cytoplasmic dynein 1b, which …
Dynein light intermediate chain
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WebFeb 6, 2024 · A conserved interaction of the dynein light intermediate chain with dynein–dynactin effectors necessary for processivity. Nat. Commun. 2024; 9: 986. Crossref; PubMed; Scopus (53) Google Scholar]. Both interactions were resolved in Chaaban and Carter’s structure and the authors were able to identify additional contacts between … WebSep 17, 2008 · The dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes. …
WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate … WebNov 1, 1999 · Whether light intermediate chain-mediated dynein interactions are completely independent of dynactin also remains to be resolved. Examination of the behavior of GFP-pericentrin in living cells has revealed clear centripetal transport of pericentrin-containing particles to the centrosome (Young, A., R. Tuft, J. Dictenberg, A. …
WebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which … WebDynein axonemal intermediate chain 1 is a protein that in humans is encoded by the DNAI1 gene. ... The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor ...
WebDec 23, 2016 · Dynein is a large, non-covalent cytoplasmic complex of protein subunits including heavy chains, intermediate chains, light …
WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. northlab 123654WebNov 23, 2024 · Central to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150 Glued and nuclear distribution protein (NudE) at overlapping sites of its intrinsically disordered N-terminal domain. The disorder in IC has hindered cryo-electron ... north laboratoryWebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … northlabWeb1 day ago · All light and intermediate chains are present, and only the ODA-DC complex is missing (Rao et al, 2024). ... The stalks of the dynein heads in this intermediate … north la auto title ruston laWebThese complex and large molecules consist of dynein heavy chains (DHC), dynein light chains (DLC), and dynein intermediate chains (DIC). While DHC binds to MTs, DLCs are involved in binding to cargo EEs. The activity of dynein is regulated by a number of factors including dynactin, i.e., a multi-subunit protein complex that plays several roles ... how to say methodistWebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … how to say methodologynorthlabs