Structural correlates of rotavirus cell entry
WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 … WebApr 13, 2024 · It has been proposed that rotavirus cell entry is a multistep process, which involves the two virus surface proteins and several cellular molecules, including sialic …
Structural correlates of rotavirus cell entry
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WebNov 5, 2014 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy noticeprivacy notice WebStructural Insights into Rotavirus Entry Adv Exp Med Biol. 2024;1215:45-68. doi: 10.1007/978-3-030-14741-9_3. ... Rotavirus entry into the cell is a complex multistep process initiated by the interaction of the tip of the viral spike with glycan ligands at the cell surface, and driven by conformational changes of the proteins present in the ...
WebNov 9, 2024 · The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific … WebFeb 11, 2024 · Human rotavirus A (RVA) causes acute gastroenteritis in infants and young children. The broad use of two vaccines, which are based on RVA strains from Europe and North America, significantly reduced rotavirus disease burden worldwide. However, a lower vaccine effectiveness is recorded in some regions of the world, such as sub-Saharan …
WebAug 14, 2024 · Abstract: Group C rotavirus (RVC) has been described to be a causative agent of gastroenteritis in humans and animals including pigs, cows, and dogs. Fecal samples collected from asymptomatic pigs in smallholder swine farms in Kenya and Uganda were screened for the presence of group C rotaviruses (RVC) using a reverse transcription … WebMay 1, 2006 · Rotaviruses recognize several cell-surface molecules, including the α 2 β 1 integrin, and the processes of rotavirus cell attachment and entry appear to be multifactorial. The VP5* subunit of the rotavirus spike protein VP4 contains the α 2 β 1 ligand sequence Asp–Gly–Glu at residues 308–310. Binding to α 2 β 1 and infectivity of …
WebMay 5, 2024 · Three-dimensional visualization of the rotavirus hemagglutinin structure. Cell 74 , 693–701 (1993). Article CAS PubMed PubMed Central Google Scholar
http://www.idi.harvard.edu/investigators_research/publication/structural_correlates_of_rotavirus_cell_entry/kirchhausen_lab/ mstc blackboardWebElectron microscopy shows images of particles at various stages of engulfment into tightly fitting membrane invaginations, consistent with the interpretation that rotavirus particles … how to make link whatsappWebAug 4, 2024 · The finding that VP6-specific IgG protect mice against rotavirus infection has important implications for rotavirus vaccination. Current assays determine protection in humans predominantly by measuring rotavirus-specific IgA titres. Measurements of VP6-specific IgG may add to existing mechanistic correlates of protection. mstcbookstore.redshelf.comWeb16 hours ago · The 3D structure of the chimeric vaccine protein was ... but the outer layer of the double-layered particles (DLPs), which are formed after viral entry on host cells [10]. This protein is the most abundant in the RV ... A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells. J. Virol., 74 (2000), pp. 11663-11670. mstc balance sheetWebMay 13, 2024 · Sixty spikes between 10 and 12 nm in length protrude from the outer capsid. The viral proteins VP1, VP2, VP3, VP4, VP6 and VP7 are structural proteins that form the virion. The non-structural ... how to make linoleum shineWebCell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA viruses, a complete subviral particle. ... Structural Correlates of Rotavirus Cell Entry. Abdelhakim A; Salgado E; Fu X; et al. See more; PLoS Pathogens (2014) 10(9) DOI: 10.1371/journal.ppat.1004355. 22 Citations ... mstc bank auction siteWeb(2014) Abdelhakim et al. PLoS Pathogens. Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA … mstc bid sheet